Refers to excessive production of androgens by
– either an increased conversion of androgen particularly testosterone, from steroid precursors by certain peripheral tissues.
This is common endocrinopathy and clinically presents as hirsutism or virilisation.
There are 3 principle laboratory measurements of potential clinical use for evaluation of androgen excess.
1. Testosterone- a measure of
ovarian and adrenal activity.
( dehydroepiandrostenedione sulphate)
– a measure of adrenal activity.
3. 3 alpha-AG
– a measure of peripheral target tissue activity.
Occasionally women with hirsutism and irregular periods may have hyperprolactinemia due to hypothalamic disease or a pituitary tumour.
Hirsutism may be ovarian factor or adrenal factor or mixed . This mixed type ovarian as well as adrenal is the commonest.
DHEAS- remain normal or slightly increase in young women with androgen excess.
High value above 800Ug/dL in a young women suggest presence of adrenal tumor.
The most common finding associated with hyperandrogenism is the androgenic polycystic ovary.
Amrutwel Women’s Clinic